1899 in America. As law enforcement pursues the last outlaw gangs, the wild west era is coming to an end. Those who refuse to give up or give in are put to death. Arthur Morgan and the Van der Linde gang are forced to escape after a robbery in the western town of Blackwater goes horribly wrong. The gang must rob, steal, and fight their way across the untamed American heartland in order to survive, with federal agents and the country's top bounty hunters swarming on their heels. Arthur is forced to choose between his allegiance to the gang that reared him and his own values as growing internal conflicts threaten to split the group apart.